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KMID : 0369819940240010041
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Jorunal of Korean Pharmaceutical Sciences
1994 Volume.24 No. 1 p.41 ~ p.48
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Controlled Drug Delivery of Ampicillin - Poly ( L - lactic acid ) Films for the Treatment of Otitis Media
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나성범/La SB
정서영/박기동/전성균/구현철/양승은/지웅길/Jeong SY/Park KD/Juhn SK/Goo HC/Yang SE/Jee UK
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Abstract
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A new local drug delivery device to treat otitis media (OM) has been developed. This device consists of a biodegradable poly(L-lactic acid) (PLLA) film containing antibiotic (ampicillin, AMP), which can be placed into the middle ear cavity and release the therapeutic concentration of AMP for prolonged period. Biodegradable films containing AMP (10 w/w%) were prepared by solution casting method using a suspension of the drug in a PLLA/CH2Cl2 solution (molecular weight of PLLA, 100,000 (100 K) and 300,000 (300 K), respectively). PLLA-AMP films were characterized by FTIR, DSC, and SEM. In vitro release of AMP from AMP-PLLA films were examined. The release pattern of AMP from AMP-PLLA films remained consistent from 1 day to 14 days, and the release rates of AMP from AMP-100K-PLLA film and AMP-300K-PLLA film were 0.7384μg/ml/day, 0.4107μg/ml/day, respectively.
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KEYWORD
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Biodegradable film, Poly(L-lactic acid), Local drug delivery system, Ampicillin
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FullTexts / Linksout information
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Listed journal information
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